Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans.

@article{Chou2009OxidationspecificEA,
  title={Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans.},
  author={Meng-Yun Chou and L Fogelstrand and Karsten Hartvigsen and Lotte F. Hansen and Douglas A Woelkers and Peter X Shaw and Jeomil Choi and Thomas Perkmann and Fredrik B{\"a}ckhed and Yury I. Miller and Sohvi H{\"o}rkk{\"o} and Maripat Corr and Joseph L. Witztum and Christoph J. Binder},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 5},
  pages={1335-49}
}
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of oxidized lipoproteins and apoptotic cells. Adaptive immune responses to various oxidation-specific epitopes play an important role in atherogenesis. However, accumulating evidence suggests that these epitopes are also recognized by innate receptors, such as scavenger receptors on macrophages, and plasma proteins, such as C-reactive protein (CRP). Here, we provide multiple lines of evidence that oxidation… CONTINUE READING
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