Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events.

@article{Tsimikas2012OxidationspecificBP,
  title={Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events.},
  author={Sotirios Tsimikas and Johann Willeit and Peter Santer and Manuel Mayr and Qingbo Xu and Agnes Mayr and Joseph L. Witztum and Stefan Kiechl},
  journal={Journal of the American College of Cardiology},
  year={2012},
  volume={60 21},
  pages={
          2218-29
        }
}
OBJECTIVES This study sought to assess the long-term predictive value and net reclassification for risk of cardiovascular disease (CVD) of biomarkers reflecting oxidation-specific epitopes (OSEs). BACKGROUND OSEs are immunogenic, proinflammatory, and proatherogenic. The long-term predictive value and net reclassification of OSEs for risk of CVD events are not known. METHODS Oxidized phospholipids on apolipoprotein B-100 (OxPL/apoB) and immunoglobulin (Ig)-G (IgG) and IgM autoantibodies to… CONTINUE READING
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