Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.

@article{Weibrecht2007OxidationSO,
  title={Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.},
  author={Irene Weibrecht and Sylvia-Annette B{\"o}hmer and Markus Dagnell and Kai Kappert and Arne Ostman and Frank-D Boehmer},
  journal={Free radical biology & medicine},
  year={2007},
  volume={43 1},
  pages={
          100-10
        }
}
Reversible oxidation of the catalytic cysteine of protein-tyrosine phosphatases (PTPs) has emerged as a putative mechanism of activity regulation by physiological cell stimulation with growth factors, and by cell treatments with adverse agents such as UV irradiation. We compared SHP-1 and SHP-2, two structurally related cytoplasmic protein-tyrosine phosphatases with different cellular functions and cell-specific expression patterns, for their intrinsic susceptibility to oxidation by H(2)O(2… CONTINUE READING
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