Oxidation-responsive polymeric vesicles.

  title={Oxidation-responsive polymeric vesicles.},
  author={Alessandro Napoli and Massimiliano Valentini and Nicola Tirelli and Martin M{\"u}ller and Jeffrey A Hubbell},
  journal={Nature materials},
  volume={3 3},
Vesicles formed in water by synthetic macro-amphiphiles have attracted much attention as nanocontainers having properties that extend the physical and chemical limits of liposomes. We sought to develop ABA block copolymeric amphiphiles that self-assemble into unilamellar vesicles that can be further oxidatively destabilized. We selected poly(ethylene glycol) (PEG) as the hydrophilic A blocks, owing to its resistance to protein adsorption and low toxicity. As hydrophobic B blocks, we selected… CONTINUE READING


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