Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage.

  title={Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage.},
  author={Francisco J Sch{\"o}pfer and Natalia A. Riobo and Mar{\'i}a Cecilia Carreras and Beatriz {\'A}lvarez and Rafael Radi and Alejandro D Boveris and Enrique Cadenas and Juan Jos{\'e} Poderoso},
  journal={The Biochemical journal},
  volume={349 Pt 1},
A major pathway of nitric oxide utilization in mitochondria is its conversion to peroxynitrite, a species involved in biomolecule damage via oxidation, hydroxylation and nitration reactions. In the present study the potential role of mitochondrial ubiquinol in protecting against peroxynitrite-mediated damage is examined and the requirements of the mitochondrial redox status that support this function of ubiquinol are established. (1) Absorption and EPR spectroscopy studies revealed that the… CONTINUE READING


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