Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

@inproceedings{Cohen2015OxidationOT,
  title={Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation},
  author={E Suzanne Cohen and Ian C Scott and Jayesh B. Majithiya and Laura Rapley and Benjamin P Kemp and Elizabeth England and D. W. G. Rees and Catherine L Overed-Sayer and Joanne Woods and Nicholas J. Bond and Christel S{\'e}guy Veyssier and Kevin J. Embrey and Dorothy A. Sims and Michael R Snaith and Katherine A. Vousden and Martin D Strain and Denice Tsz Yau Chan and Sara Paolita del Carmen and Catherine E Huntington and Liz Flavell and Jianqing Xu and Bojana Popovic and Christopher E Brightling and Tristan J Vaughan and Robin Butler and David Lowe and Daniel R. Higazi and Dominic J. Corkill and Richard D May and Matthew A Sleeman and Tomas Mustelin},
  booktitle={Nature communications},
  year={2015}
}
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, resulting in an extensive conformational change that disrupts the ST2 binding site. Both reduced (active… CONTINUE READING

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