Oxidation of synephrine by type A and type B monoamine oxidase

@article{Suzuki1979OxidationOS,
  title={Oxidation of synephrine by type A and type B monoamine oxidase},
  author={Osamu Suzuki and T. Matsumoto and Masakazu Oya and Yoshinao Katsumata},
  journal={Experientia},
  year={1979},
  volume={35},
  pages={1283-1284}
}
Synephrine (SP) was found to be a substrate for monoamine oxidase (MAO) in rat brain mitochondria, showing the Km and Vmax values of 250 μM and 32.6 nmoles/mg of protein/30 min respectively. The inhibition studies showed that the SP oxidation was carried out by both type A and type B MAO and a major part of the activity was due to type A MAO. 

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References

SHOWING 1-10 OF 14 REFERENCES

Multiplicity of monoamine oxidase in chick brain

It was found that neither 5-hydroxytryptamine nor β-phenylethylamine is the specific substrate for type A and type B MAO in chick brain.

Beta-phenylethylamine: a specific substrate for type B monoamine oxidase of brain.

  • H. Y. YangN. Neff
  • Chemistry, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1973
It is concluded that the amines of brain may be cataboblized by specific types of monoamine oxidase in vivo.

A kinetic evaluation of monoamine oxidase activity in rat liver mitochondrial outer membranes.

1. A preparation of mitochondrial outer membranes from rat liver can be shown to contain two kinetically distinct monoamine oxidase activities. These activities are distinguishable by their different

Biosynthesis of cerebral phenolic amines. I. In vivo formation of p-tyramine, octopamine, and synephrine.

Differences in the amounts of the phenolicamines formed suggest that mechanisms other than just decarboxylation are involved in the formation of phenolic amines.

The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines.

  • H. Y. YangN. Neff
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1974
It is postulate that it may be possible to alter selectively the metabolism of the putative transmitter amines in man by administration of monoamine oxidase inhibitor drugs that preferentially inactivate a specific type of monoamines.

Identification of p-hydroxy-alpha-(methylaminomethyl) benzyl alcohol (synephrine) in human urine.

Studies by a variety of procedures have definitely established its identity as p-hydroxy-oc-(methylaminomethyl)benzyl alcohol (synephrine, Sympatol), which suggested that the unknown base in urine was a derivative of p-Hydroxyphenylethanolamine.

A simple and sensitive fluorescence assay for monoamine oxidase and diamine oxidase.

  • S. SnyderE. Hendley
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1968
Diamine oxidase from rat small intestine oxidized putrescine, cadaverine, histamine and 1,4- methyl histamine, but appeared to have a greater affinity for histamine than for the other sub strates tested, while monoamine oxidase in rat brain and liver had the same relative activities toward a number of substrates.

The phenolic amines of human urine.