Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?

@article{Sesti2010OxidationOP,
  title={Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?},
  author={Federico Sesti and Shuang Liu and S. Cai},
  journal={Trends in cell biology},
  year={2010},
  volume={20 1},
  pages={45-51}
}
A wealth of evidence underscores the tight link between oxidative stress, neurodegeneration and aging. When the level of excess reactive oxygen species (ROS) increases in the cell, a phenomenon characteristic of aging, DNA is damaged, proteins are oxidized, lipids are degraded and more ROS are produced, all culminating in significant cell injury. Recently we showed that in the nematode, Caenorhabditis elegans, oxidation of K(+) channels by ROS is a major mechanism underlying the loss of… CONTINUE READING