Oxidation of methionine residues of proteins: biological consequences.

  title={Oxidation of methionine residues of proteins: biological consequences.},
  author={Earl R. Stadtman and Jackob Moskovitz and Rodney L Levine},
  journal={Antioxidants & redox signaling},
  volume={5 5},
Most reactive oxygen species (ROS) can oxidize methionine (Met) residues of proteins to methionine sulfoxide (MetO). However, unlike the ROS-dependent oxidation of other amino acid residues of proteins (except cysteine residues), the oxidation of Met residues is readily reversed by the action of methionine sulfoxide reductase (Msr) that catalyzes the thioredoxin-dependent reduction of MetO residues of proteins back to Met. We summarize here results of studies showing that the cyclic… CONTINUE READING
97 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 97 extracted citations

Similar Papers

Loading similar papers…