Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen.

@article{Wefers1983OxidationOG,
  title={Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen.},
  author={H Wefers and Helmut Sies},
  journal={European journal of biochemistry},
  year={1983},
  volume={137 1-2},
  pages={29-36}
}
The reaction of superoxide with reduced glutathione (GSH) was studied with two O-.2-producing systems: xanthine oxidase using xanthine or acetaldehyde as substrates, and secondly, quinol autoxidation. The capability of GSH to quench superoxide radicals was detected by lowered O-.2-mediated cytochrome c3+ reduction. The formation of the oxidation products, glutathione disulfide (GSSG) and glutathione sulfonate (the latter at levels of about 6-15% compared to GSSG), was dependent on the O-.2… CONTINUE READING

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