Oxidation of glucosamine by human polymorphonuclear leukocytes

@article{Swendsen2004OxidationOG,
  title={Oxidation of glucosamine by human polymorphonuclear leukocytes},
  author={Charles L. Swendsen and Lawrence R. Dechatelet},
  journal={Inflammation},
  year={2004},
  volume={5},
  pages={71-80}
}
  • Charles L. Swendsen, Lawrence R. Dechatelet
  • Published 2004
  • Chemistry, Medicine
  • Inflammation
  • When exposed to a phagocytic stimulus (opsonized zymosan), human polymorphonuclear leukocytes (PMNs) produced14CO2 from [1-14C]glucosamine at a rate 10–25% of that produced from glucose under the same conditions. The production of CO2 from glucosamine by intact PMNs was inhibited by glucose and dependent upon activation of the hexosemonophosphate shunt (HMPS). However, the metabolic pathways for the oxidation of glucose and glucosamine by PMNs are not identical. This is suggested by the fact… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 16 REFERENCES
    Glucose-6-phosphate Dehydrogenase
    • 1,068
    [12] Colorimetric analysis of sugars
    • 826
    A modified procedure for the determination of leukocyte alkaline phosphatase.
    • 146
    Catabolism of 2-deoxyglucose by phagocytic leukocytes in the presence of 12-O-tetradecanoyl phorbol-13-acetate.
    • 27
    • Open Access
    Stimulation of leukocyte hexose monophosphate shunt activity by ascorbic Acid.
    • 34
    • Open Access
    Determination of submicro quantities of ammonia.
    • 45
    Colorimetric analysis of sugars
    • 1957