Oxidation of Met144 and Met145 in calmodulin blocks calmodulin dependent activation of the plasma membrane Ca-ATPase.

@article{Bartlett2003OxidationOM,
  title={Oxidation of Met144 and Met145 in calmodulin blocks calmodulin dependent activation of the plasma membrane Ca-ATPase.},
  author={Ryan K. Bartlett and Ramona J Bieber Urbauer and Asokan Anbanandam and Heather S Smallwood and Jeffrey L. Urbauer and Thomas C Squier},
  journal={Biochemistry},
  year={2003},
  volume={42 11},
  pages={3231-8}
}
Methionine oxidation in calmodulin (CaM) isolated from senescent brain results in an inability to fully activate the plasma membrane (PM) Ca-ATPase, which may contribute to observed increases in cytosolic calcium levels under conditions of oxidative stress and biological aging. To identify the functional importance of the oxidation of Met(144) and Met(145) near the carboxyl-terminus of CaM, we have used site-directed mutagenesis to substitute leucines for methionines at other positions in CaM… CONTINUE READING

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