Oxidation of Linoleic Acid in Low-Density Lipoprotein: An Important Event in Atherogenesis.

@article{Spiteller2000OxidationOL,
  title={Oxidation of Linoleic Acid in Low-Density Lipoprotein: An Important Event in Atherogenesis.},
  author={Spiteller},
  journal={Angewandte Chemie},
  year={2000},
  volume={39 3},
  pages={585-589}
}
Contrary to earlier views the main oxidation products of low-density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as 1 and 2 have been identified for the first time, is obtained from minimally oxidized (that is, aged) LDL. Since this is still recognized by the LDL receptor, it is concluded that toxic oxidation… CONTINUE READING

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