Oxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous medium.

@article{NezVergara2007OxidationOC,
  title={Oxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous medium.},
  author={Luis Joaqu{\'i}n N{\'u}{\~n}ez-Vergara and Ricardo Salazar and Cristi{\'a}n Camargo and Jaime Carbajo and Bernardo Jorge L Conde and P A Navarrete-Encina and Juan Arturo Squella},
  journal={Bioorganic & medicinal chemistry},
  year={2007},
  volume={15 12},
  pages={4318-26}
}
This work reports the electrochemical oxidation of three newly synthesized C4-hydroxyphenyl-substituted 1,4-dihydropyridine derivatives in dimethylsulfoxide. The reactivity of the compounds with ABAP-derived alkylperoxyl radicals in aqueous buffer pH 7.4, was also studied. The oxidation mechanism involves the formation of the unstable dihydropyridyl radical, which was confirmed by controlled-potential electrolysis (CPE) and ESR experiments. The final product of the CPE, that is, pyridine… CONTINUE READING
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