Corpus ID: 1396498

Oxidation of 2-thioflavins by peroxides. Formation of flavin 2-S-oxides.

  title={Oxidation of 2-thioflavins by peroxides. Formation of flavin 2-S-oxides.},
  author={M. Biemann and A. Claiborne and S. Ghisla and V. Massey and P. Hemmerich},
  journal={The Journal of biological chemistry},
  volume={258 9},
  • M. Biemann, A. Claiborne, +2 authors P. Hemmerich
  • Published 1983
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • The reaction of 2-thioriboflavin (sulfur replacing the oxygen substituent at position 2 alpha) with hydrogen peroxide at pH approximately 10 leads to a blue flavin (lambda max = 565 nm) which was purified in stable, homogeneous form. Titrations of 2-thioflavins with m-chloroperoxybenzoic acid also yield the same blue flavins with consumption of 1 eq of peracid. Anaerobic reduction of the blue flavin by sodium dithionite requires 4e- eq, and leads to formation of 1,5-dihydro-2-thioflavin… CONTINUE READING
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