Oxidation of 2-thioflavins by peroxides. Formation of flavin 2-S-oxides.

@article{Biemann1983OxidationO2,
  title={Oxidation of 2-thioflavins by peroxides. Formation of flavin 2-S-oxides.},
  author={M Biemann and A. K. Claiborne and Sandro Ghisla and Vincent Massey and P H Hemmerich},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 9},
  pages={5440-8}
}
The reaction of 2-thioriboflavin (sulfur replacing the oxygen substituent at position 2 alpha) with hydrogen peroxide at pH approximately 10 leads to a blue flavin (lambda max = 565 nm) which was purified in stable, homogeneous form. Titrations of 2-thioflavins with m-chloroperoxybenzoic acid also yield the same blue flavins with consumption of 1 eq of… CONTINUE READING