Oxidation of 2',7'-dichlorofluorescin by peroxynitrite.

  title={Oxidation of 2',7'-dichlorofluorescin by peroxynitrite.},
  author={Neil W. Kooy and John Royall and Harry Ischiropoulos},
  journal={Free radical research},
  volume={27 3},
The simultaneous production of nitric oxide and superoxide anion leads to the formation of peroxynitrite, a potent oxidant which may be an important mediator of cellular injury. Oxidation of dichlorofluorescin to the fluorescent dichlorofluorescein has been used as a marker for cellular oxidant production. The mechanisms of peroxynitrite-mediated oxidation of dichlorofluorescin to dichlorofluorescein were investigated. Chemically synthesized peroxynitrite (50-500 nM) induced the oxidation of… CONTINUE READING


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