Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling

@article{Hewitson2005OxidationB2,
  title={Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling},
  author={Kirsty S. Hewitson and Nicolas Granatino and Richard W. D. Welford and Michael A. McDonough and Christopher J. Schofield},
  journal={Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
  year={2005},
  volume={363},
  pages={807 - 828}
}
  • K. Hewitson, N. Granatino, +2 authors C. Schofield
  • Published 2005
  • Chemistry, Medicine, Biology
  • Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
The 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases are a superfamily of enzymes that catalyse a wide range of reactions including hydroxylations, desaturations and oxidative ring closures. Recently, it has been discovered that they act as sensors in the hypoxic response in humans and other animals. Substrate oxidation is coupled to conversion of 2OG to succinate and carbon dioxide. Kinetic, spectroscopic and structural studies are consistent with a consensus mechanism in which… Expand
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