Oxidation as a post-translational modification that regulates autophagy.

  title={Oxidation as a post-translational modification that regulates autophagy.},
  author={Ruth Scherz-Shouval and Elena Shvets and Zvulun Elazar},
  volume={3 4},
The toxicity associated with accumulation of reactive oxygen species (ROS) has led to the evolution of various defense strategies to overcome oxidative stress, including autophagy. This pathway is involved in the removal and degradation of damaged mitochondria and oxidized proteins. At low levels, however, ROS act as signal transducers in various intracellular pathways. In a recent study we described the role of ROS as signaling molecules in starvation-induced autophagy. We showed that… CONTINUE READING
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