Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism.

@article{Jourdheuil2003OxidationAN,
  title={Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism.},
  author={David Jourd'heuil and Frances L. Jourd'heuil and Martin Feelisch},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 18},
  pages={15720-6}
}
Although the nitric oxide (.NO)-mediated nitrosation of thiol-containing molecules is increasingly recognized as an important post-translational modification in cell signaling and pathology, little is known about the factors that govern this process in vivo. In the present study, we examined the chemical pathways of nitrosothiol (RSNO) production at low… CONTINUE READING