Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells.

@article{Tyurina2006OxidationAC,
  title={Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells.},
  author={Yulia Y. Tyurina and Alexander A. Kapralov and Jianfei Jiang and Grigory G. Borisenko and Alla I. Potapovich and Andrey Sorokin and Patrick M Kochanek and Steven H Graham and Nina F Schor and Valerian E Kagan},
  journal={Brain research},
  year={2006},
  volume={1093 1},
  pages={71-82}
}
Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, likely associated with dysregulation of oxidation of catechols, such as dopamine (DA) and 6-hydroxydopamine (6-OHDA), and resulting in oxidative stress. The involvement of cyclooxygenase-2 (COX-2) in pathogenesis of Parkinson's disease has been suggested. However, specific… CONTINUE READING