Oxidation and Storage of Glucose under the Action of Insulin

  title={Oxidation and Storage of Glucose under the Action of Insulin},
  author={Charles Herbert Best and Henry Hallett Dale and J. P. Hoet and H. P. Marks},
  journal={Proceedings of The Royal Society B: Biological Sciences},
  • C. Best, H. Dale, H. Marks
  • Published 1 June 1926
  • Biology
  • Proceedings of The Royal Society B: Biological Sciences
Experiments published by three of us (B., H., and M.) (1) have demonstrated that, in a spinal animal with the muscles at rest, a large part of the glucose disappearing from the circulation under the action of insulin is deposited as glycogen in the muscles. The view that the remainder, which was in most cases the larger, and in some cases the much larger part, had been oxidized, was quite compatible with the observations of Burn and Dale (2), who had measured the oxygen consumption, but not the… 
Insulin and Muscle
Changes in the Respiratory Quotient after Administration of Insulin and Glucose to Human Subjects on a High and on a Low Carbohydrate Diet.
The characteristic high and long glucose tolerance curve on a diet poor in carbohydrates must be due to a liver effect, even though it is not at present possible to account for the mechanism of this process.
New Views on the Metabolism of Carbohydrate and Fat and its Relation to Insulin: Some Results with the High Carbohydrate—Low Fat Diet in Diabetes
  • E. P. Poulton
  • Medicine
    Proceedings of the Royal Society of Medicine
  • 1933
Benedict and Carpenter, DuBois and his colleagues, and Murlin and Lusk have measured directly in a calorimeter the heat output of a man or animal under basal conditions and drawn the conclusion from average values that agreement between the two was sufficiently satisfactory, and justified the theory on which indirect calorimetry was based.
Effect of High Blood Sugar Levels upon Splanchnic Sugar Output in Experimental Diabetes
In situ measurements showed that the artificially induced hyperglycemia enhances the sugar uptake of the pancreatectomized dog's muscle three to fourfold and the relationship between the splanchnic sugar output and the blood sugar level was investigated.
Cell Biology of Insulin Action on Glucose Transport and Its Perturbation in Diabetes Mellitus
Recent progress in understanding the mechanisms by which insulin stimulates glucose entry into muscle and adipose cells will be described and the direct application of these mechanisms to the pathophysiology of diabetes mellitus and its reversal with insulin therapy will be discussed.
Synthesis of muscle glycogen during recovery after prolonged severe exercise in diabetic subjects. Effect of insulin deprivation.
The effect of insulin deprivation on muscle glycogen resynthesis during 12 h of resting recovery after exhaustive exercise was studied in five young juvenile diabetic subjects. The subjects were
Insulin Action: 1948–80
Insulin is an old hormone from the standpoint of evolution and has effects on growth and glucose uptake in animals low on the evolutionary ladder, yes even unicellular organisms and Csaba has reviewed recently the work with more primitive species.
Concerning the Mechanisms of Insulin Action: The Banting Memorial Lecture 1961
It is an inestimable privilege to be able to share with you some thoughts concerning the mechanisms of action of that hormone, which Banting and Best brought to light forty years ago this summer. I
Mechanisms of Insulin Action and Insulin Resistance.
This work aims to develop an integrated physiological perspective, placing the intricate signaling effectors that carry out the cell-autonomous response to insulin in the context of the tissue-specific functions that generate the coordinated organismal response.
Synthesis of muscle glycogen during recovery after prolonged severe exercise in diabetic and non-diabetic subjects.
It is concluded that glycogen synthesis during recovery following prolonged severe exercise can proceed at the same rate in diabetic subjects taking their regular insulin as in non-diabetic subjects.


On the location and nature of the action of insulin
The author mentions unsuccessful attempts to investigate the participation of skeletal muscles by adding insulin to blood artificially perfused through limbs, and states that analysis of arterial and venous blood, from the literature, is incomplete, and not altogether consistent.
A circulating scheme for recording respiratory metabolism
  • E. Schuster
  • Medicine, Biology
    The Journal of physiology
  • 1924
THE apparatus was originally designed and made at the suggestion of Dr Lovatt Evans, and in its original form was intended to record the oxygen consumption of an ansesthetised animal breathing
Versuche über die Insulinwirkung
Der respiratorische Stoffwechsel der Kaninchen wurde untersucht bei Wechsel der Ausentemperatur von 29° auf 10° unter dem Einflus des Insulins. Dabei ergab sich, das die Insulintiere nicht imstande
Oppenheimer's Handfc. d
  • Biochem
  • 1924
Proc.,’ supra
  • Burn and Dale, ‘ J. Physiol.,’
  • 1924