Oxidants and skeletal muscle function: physiologic and pathophysiologic implications.

@article{Clanton1999OxidantsAS,
  title={Oxidants and skeletal muscle function: physiologic and pathophysiologic implications.},
  author={Thomas L Clanton and Lun Zuo and Paul F. Klawitter},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1999},
  volume={222 3},
  pages={
          253-62
        }
}
Previous studies have demonstrated that skeletal muscles generate considerable reactive oxygen during intense muscle contraction. However, the significance of this phenomenon and whether it represents normal physiology or pathology are poorly understood. Treatment with exogenous antioxidants suggests that normal redox tone during contraction is influencing ongoing contractile function, both at rest and during intense exercise. This could represent the influence of redox-sensitive proteins… CONTINUE READING
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