Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK.

  title={Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK.},
  author={Tara L. Archuleta and A. M. Lemieux and V. Saengsirisuwan and M. K. Teachey and K. Lindborg and J. Kim and E. Henriksen},
  journal={Free radical biology & medicine},
  volume={47 10},
  • Tara L. Archuleta, A. M. Lemieux, +4 authors E. Henriksen
  • Published 2009
  • Biology, Medicine
  • Free radical biology & medicine
  • Oxidative stress is characterized as an imbalance between the cellular production of oxidants and the cellular antioxidant defenses and contributes to the development of numerous cardiovascular and metabolic disorders, including hypertension and insulin resistance. The effects of prolonged oxidant stress in vitro on the insulin-dependent glucose transport system in mammalian skeletal muscle are not well understood. This study examined the in vitro effects of low-level oxidant stress (60-90… CONTINUE READING
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