Oxidant stress evoked damage in rat hepatocyte leading to triggered nitric oxide synthase (NOS) levels on long term consumption of aspartame.

@article{Ashok2015OxidantSE,
  title={Oxidant stress evoked damage in rat hepatocyte leading to triggered nitric oxide synthase (NOS) levels on long term consumption of aspartame.},
  author={Iyaswamy Ashok and Rathinasamy Sheeladevi},
  journal={Journal of food and drug analysis},
  year={2015},
  volume={23 4},
  pages={
          679-691
        }
}
  • Iyaswamy Ashok, Rathinasamy Sheeladevi
  • Published 2015
  • Chemistry, Medicine
  • Journal of food and drug analysis
  • This study investigates how long-term (40 mg/kg b.wt) consumption of aspartame can alter the antioxidant status, stress pathway genes, and apoptotic changes in the liver of Wistar albino rats. Numerous controversial reports are available on the use of aspartame as it releases methanol as one of its metabolites during metabolism. To mimic the human methanol metabolism the methotrexate treated rats were included to study the aspartame effects. The aspartame treated methotrexate (MTX animals… CONTINUE READING

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