Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK.

  title={Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK.},
  author={J. Kim and V. Saengsirisuwan and J. Sloniger and M. K. Teachey and E. Henriksen},
  journal={Free radical biology & medicine},
  volume={41 5},
  • J. Kim, V. Saengsirisuwan, +2 authors E. Henriksen
  • Published 2006
  • Chemistry, Medicine
  • Free radical biology & medicine
  • Oxidative stress can impact the regulation of glucose transport activity in a variety of cell lines. In the present study, we assessed the direct effects of an oxidant stress on the glucose transport system in intact mammalian skeletal muscle preparations. Type IIb (epitrochlearis) and type I (soleus) muscles from insulin-sensitive lean Zucker rats were incubated in 8 mM glucose for 2 h in the absence or presence of 100 mU/ml glucose oxidase to produce the oxidant hydrogen peroxide (H(2)O(2… CONTINUE READING
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