Oxidant stress and potentiation of ischemia/reperfusion injury to the perfused rat liver by human polymorphonuclear leukocytes.

@article{Bilzer1994OxidantSA,
  title={Oxidant stress and potentiation of ischemia/reperfusion injury to the perfused rat liver by human polymorphonuclear leukocytes.},
  author={Manfred Bilzer and Bernhard H. Lauterburg},
  journal={Journal of hepatology},
  year={1994},
  volume={20 4},
  pages={473-7}
}
The accumulation and activation of polymorphonuclear leukocytes in the liver may play an important role in liver damage following ischemia and reperfusion. To study the effects of polymorphonuclear leukocytes on hepatic function, human polymorphonuclear leukocytes were infused into perfused rat livers. Infusion of polymorphonuclear leukocytes into continuously oxygenated livers led to an increased consumption of oxygen by the perfused liver which paralleled the production of superoxide anion… CONTINUE READING