Oxidant sensing by reversible disulfide bond formation.

  title={Oxidant sensing by reversible disulfide bond formation.},
  author={Claudia M. Cremers and Ursula Jakob},
  journal={The Journal of biological chemistry},
  volume={288 37},
Maintenance of the cellular redox balance is crucial for cell survival. An increase in reactive oxygen, nitrogen, or chlorine species can lead to oxidative stress conditions, potentially damaging DNA, lipids, and proteins. Proteins are very sensitive to oxidative modifications, particularly methionine and cysteine residues. The reversibility of some of these oxidative protein modifications makes them ideally suited to take on regulatory roles in protein function. This is especially true for… CONTINUE READING
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