Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing.

@article{Sen2002OxidantinducedVE,
  title={Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing.},
  author={Chandan K. Sen and Savita Khanna and Bernard M. Babior and Thomas K. Hunt and Edwin Christopher Ellison and Sashwati Roy},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 36},
  pages={33284-90}
}
Neutrophils and macrophages, recruited to the wound site, release reactive oxygen species by respiratory burst. It is commonly understood that oxidants serve mainly to kill bacteria and prevent wound infection. We tested the hypothesis that oxidants generated at the wound site promote dermal wound repair. We observed that H(2)O(2) potently induces vascular endothelial growth factor (VEGF) expression in human keratinocytes. Deletion mutant studies with a VEGF promoter construct revealed that a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 95 extracted citations

References

Publications referenced by this paper.
Showing 1-4 of 4 references

Current Topics in Microbiology & Immunology 237, 41-57 by gest on Jauary 8, 2018 hp://w w w .jb.org/ D ow nladed from Redox control of wound repair

  • U. Eriksson, K. Alitalo
  • 1999

hp://w w w .jb.org/ D ow nladed from Redox control of wound repair

  • F. Kheradmand, E. Werner, P. Tremble, M. Symons, Z. Werb
  • Science
  • 1998

Theory and practice of histological techniques

  • J. D. Bancroft, A. Stevens
  • 1996

Similar Papers

Loading similar papers…