Oxidant-induced apoptosis of glomerular cells: intracellular signaling and its intervention by bioflavinoid.

Abstract

Oxidant stress plays a crucial role in the generation of a wide range of glomerular disease. In the first part of this article, we describe intracellular signaling pathways involved in the oxidant-initiated apoptosis of mesangial cells, especially highlighting the tyrosine kinase-c-Jun/AP-1 pathway. In the second part, we address a novel potential of bioflavonoid quercetin as an inhibitor of apoptosis in glomerular cells. Possible mechanisms for the antiapoptotic action of quercetin and its therapeutic utility are discussed.

Cite this paper

@article{Kitamura1999OxidantinducedAO, title={Oxidant-induced apoptosis of glomerular cells: intracellular signaling and its intervention by bioflavinoid.}, author={Mineaki Kitamura and Yoshihioro Ishikawa}, journal={Kidney international}, year={1999}, volume={56 4}, pages={1223-9} }