Oxidant-antioxidant balance in granulocytes during ARDS. Effect of N-acetylcysteine.

@article{Laurent1996OxidantantioxidantBI,
  title={Oxidant-antioxidant balance in granulocytes during ARDS. Effect of N-acetylcysteine.},
  author={Thierry Laurent and Matthew Markert and F. Feihl and M. D. Schaller and Claude Perret},
  journal={Chest},
  year={1996},
  volume={109 1},
  pages={
          163-6
        }
}
  • Thierry Laurent, Matthew Markert, +2 authors Claude Perret
  • Published 1996
  • Medicine
  • Chest
  • The production of cytotoxic oxygen radicals by activated granulocytes is a proposed mechanism of lung injury in ARDS. Protective effects of N-acetylcysteine (NAC) have been described in experimental and clinical ARDS. NAC could act in part by replenishing the intracellular stores of glutathione (GSH) in activated granulocytes, leading to detoxification of oxygen radicals produced by these cells. To test this hypothesis, 16 patients in the early phase of ARDS were randomized to receive either… CONTINUE READING

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