Oxidant-Sensing Pathways in the Responses of Fungal Pathogens to Chemical Stress Signals

@inproceedings{Simaan2019OxidantSensingPI,
  title={Oxidant-Sensing Pathways in the Responses of Fungal Pathogens to Chemical Stress Signals},
  author={Hiba Simaan and Sophie Lev and Benjamin A. Horwitz},
  booktitle={Front. Microbiol.},
  year={2019}
}
Host defenses expose fungal pathogens to oxidants and antimicrobial chemicals. The fungal cell employs conserved eukaryotic signaling pathways and dedicated transcription factors to program its response to these stresses. The oxidant-sensitive transcription factor of yeast, YAP1, and its orthologs in filamentous fungi, are central to tolerance to oxidative stress. The C-terminal domain of YAP1 contains cysteine residues that, under oxidizing conditions, form an intramolecular disulfide bridge… CONTINUE READING

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