Oxazolidinone antibiotics.

  title={Oxazolidinone antibiotics.},
  author={Daniel J. Diekema and Ronald N. Jones},
  volume={358 9297},
Many common gram-positive pathogens (eg, Staphylococcus aureus, Enterococcus spp, and Streptococcus pneumoniae) have become increasingly resistant to antimicrobial agents, and new drugs with activity against gram-positive bacteria are urgently needed. The oxazolidinones, a new chemical class of synthetic antimicrobial agent, have a unique mechanism of inhibiting bacterial protein synthesis. Linezolid, the first oxazolidinone to be approved for clinical use, displays in-vitro activity (generally… CONTINUE READING
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