Oxandrolone Treatment in Adults with Severe Thermal Injury

  title={Oxandrolone Treatment in Adults with Severe Thermal Injury},
  author={James T. Miller and Imad F. Btaiche},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
Severe thermal injury is associated with hypermetabolism and hyper‐catabolism, leading to skeletal muscle breakdown, lean body mass loss, weight loss, and negative nitrogen balance. Muscle protein catabolism in patients with severe thermal injury is the result of stress‐induced increased release of cytokines and counterregulatory hormones. Coupled with decreased serum anabolic hormone concentrations such as testosterone and growth hormone along with the presence of insulin resistance, anabolism… 

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