Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin.

@article{Mannelli2012OxaliplatininducedNO,
  title={Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin.},
  author={Lorenzo Di Cesare Mannelli and Matteo Zanardelli and Paola Failli and Carla Ghelardini},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2012},
  volume={13 3},
  pages={276-84}
}
UNLABELLED Oxaliplatin is the standard treatment for advanced colorectal cancer. Its dose-limiting toxicity is the development of a painful neuropathic syndrome sustained by unclear mechanisms. Although the oxidative hypothesis is a matter of debate, direct data about oxidative damage induced in vivo by anticancer agents are lacking and the efficacy of the available antioxidant compounds are unsatisfactory. In a rat model of painful oxaliplatin-induced neuropathy (2.4 mgkg(-1) i.p., daily for… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS