Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1.

@article{Mannelli2015OxaliplatinEP,
  title={Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1.},
  author={Lorenzo Di Cesare Mannelli and Manuela Marcoli and Laura Micheli and Matteo Zanardelli and Guido Maura and Carla Ghelardini and Chiara Cervetto},
  journal={Neuropharmacology},
  year={2015},
  volume={97},
  pages={133-41}
}
Anticancer therapy based on the repeated administration of oxaliplatin is limited by the development of a neuropathic syndrome difficult to treat. Oxaliplatin neurotoxicity is based on complex nervous mechanisms, the comprehension of the role of single neurotransmitters and the knowledge of the signal flow among cells is matter of importance to improve… CONTINUE READING