Oxaliplatin-containing Preoperative Therapy in Locally Advanced Rectal Cancer: Local Response, Toxicity and Long-term Outcome.

@article{Dueland2016OxaliplatincontainingPT,
  title={Oxaliplatin-containing Preoperative Therapy in Locally Advanced Rectal Cancer: Local Response, Toxicity and Long-term Outcome.},
  author={Svein Dueland and Anne Hansen Ree and Krystyna Kotanska Gr\oholt and Marie Gr\on Saelen and Sigurd Folkvord and Knut H{\aa}kon Hole and Therese Seierstad and Stein Gunnar Larsen and K E Giercksky and Johan Nicolay Wiig and K Boye and Kjersti Flatmark},
  journal={Clinical oncology (Royal College of Radiologists (Great Britain))},
  year={2016},
  volume={28 8},
  pages={532-9}
}
AIMS This non-randomised study was undertaken to examine oxaliplatin as possibly an intensifying component of sequential neoadjuvant therapy in locally advanced rectal cancer for improved local and metastatic outcome. MATERIALS AND METHODS Ninety-seven patients (57 T2-3 cases, 40 T4 cases) received two cycles of the Nordic FLOX regimen (oxaliplatin 85 mg/m(2) day 1 and bolus 5-fluorouracil 500 mg/m(2) and folinic acid 100 mg days 1 and 2) before long-course chemoradiotherapy with concomitant… CONTINUE READING
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