Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord.

@article{Yamamoto2016OxaliplatinAI,
  title={Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord.},
  author={Ken Yamamoto and Mayuko Tsuboi and Toshie Kambe and Kenji Abe and Yoshihiko Nakatani and Kazuyoshi Kawakami and Iku Utsunomiya and Kyoji Taguchi},
  journal={Journal of pharmacological sciences},
  year={2016},
  volume={130 2},
  pages={117-22}
}
Oxaliplatin is a chemotherapeutic agent that is effective against various types of cancer including colorectal cancer. Acute cold hyperalgesia is a serious side effect of oxaliplatin treatment. Although the therapeutic drug pregabalin is beneficial for preventing peripheral neuropathic pain by targeting the voltage-dependent calcium channel α2δ-1 (Cavα2δ-1) subunit, the effect of oxaliplatin-induced acute cold hypersensitivity is uncertain. To analyze the contribution of the Cavα2δ-1 subunit to… CONTINUE READING