Oxaliplatin Alters Expression of T1R2 Receptor and Sensitivity to Sweet Taste in Rats.

@article{Ohishi2016OxaliplatinAE,
  title={Oxaliplatin Alters Expression of T1R2 Receptor and Sensitivity to Sweet Taste in Rats.},
  author={Akihiro Ohishi and Kentaro Nishida and Yuri Yamanaka and Ai Miyata and Akiko Ikukawa and Miharu Yabu and Karin Miyamoto and Saho Bansho and Kazuki Nagasawa},
  journal={Biological & pharmaceutical bulletin},
  year={2016},
  volume={39 4},
  pages={578-86}
}
As one of the adverse effects of oxaliplatin, a key agent in colon cancer chemotherapy, a taste disorder is a severe issue in a clinical situation because it decreases the quality of life of patients. However, there is little information on the mechanism underlying the oxaliplatin-induced taste disorder. Here, we examined the molecular and behavioral characteristics of the oxaliplatin-induced taste disorder in rats. Oxaliplatin (4-16 mg/kg) was administered to Sprague-Dawley (SD) rats… CONTINUE READING

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From the Cover: Drug-Induced Taste Disorders in Clinical Practice and Preclinical Safety Evaluation.

Toxicological sciences : an official journal of the Society of Toxicology • 2017
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