Oxaliplatin: a review in the era of molecularly targeted therapy.

  title={Oxaliplatin: a review in the era of molecularly targeted therapy.},
  author={Thierry Alcindor and N. Beauger},
  journal={Current oncology},
  volume={18 1},
OBJECTIVE To review preclinical and clinical data for oxaliplatin in the current context of molecularly targeted therapy. METHODS OF STUDY SELECTION We searched the PubMed and PubChem databases by combining the search terms "oxaliplatin" or "platinum" or both, with "clinical trials," "pharmacokinetics," and "pharmacodynamics." DATA EXTRACTION AND SYNTHESIS Oxaliplatin has a complicated pharmacokinetic profile, with activity against digestive cancers in particular. It has several mechanisms… CONTINUE READING
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