Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles.

@article{Kuo1988OxalateTV,
  title={Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles.},
  author={Shiu-Ming Kuo and Peter S. Aronson},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 20},
  pages={9710-7}
}
We evaluated the mechanism of oxalate transport in basolateral membrane vesicles isolated from the rabbit renal cortex. An outward HCO3- gradient induced the transient uphill accumulation of oxalate and sulfate, indicating the presence of oxalate/HCO3- exchange and sulfate/HCO3- exchange. For oxalate, sulfate, or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, the K1/2 value for oxalate/HCO3- exchange was nearly identical to that for sulfate/HCO3- exchange, suggesting that both exchange… CONTINUE READING

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