Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice.

@article{Mulay2016OxalateinducedCK,
  title={Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice.},
  author={Shrikant R Mulay and Jonathan N. Eberhard and Victoria Pfann and Julian A. Marschner and Murthy N Darisipudi and Christoph Daniel and Simone Romoli and Jyaysi Desai and Melissa Grigorescu and Santhosh V Kumar and Birgit Rathkolb and Eckhard Wolf and Martin Hrabě de Angelis and Tobias B{\"a}uerle and Barbara 6 Dietel and Carsten A Wagner and Kerstin Amann and Karl Eckardt and Peter S. Aronson and Hans Joachim Anders and Felix Knauf},
  journal={American journal of physiology. Renal physiology},
  year={2016},
  volume={310 8},
  pages={
          F785-F795
        }
}
Chronic kidney disease (CKD) research is limited by the lack of convenient inducible models mimicking human CKD and its complications in experimental animals. We demonstrate that a soluble oxalate-rich diet induces stable stages of CKD in male and female C57BL/6 mice. Renal histology is characterized by tubular damage, remnant atubular glomeruli, interstitial inflammation, and fibrosis, with the extent of tissue involvement depending on the duration of oxalate feeding. Expression profiling of… CONTINUE READING
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