Ovulation and menstrual function of adolescent girls with central precocious puberty after therapy with gonadotropin-releasing hormone agonists.

@article{Jay1992OvulationAM,
  title={Ovulation and menstrual function of adolescent girls with central precocious puberty after therapy with gonadotropin-releasing hormone agonists.},
  author={Nancy Jay and Maynard J. Mansfield and Robert M Blizzard and William Francis Crowley and David Sch{\"o}nfeld and L Rhubin and Paul A Boepple},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1992},
  volume={75 3},
  pages={890-4}
}
Chronic GmRH agonist (GnRHa) administration has been shown to suppress pituitary-gonadal function in children with central precocious puberty (CPP), but long term data after the reactivation of gonadarche posttherapy are not yet available. This study evaluated the menstrual function of 46 girls with CPP who had been treated for at least 2 yr with GnRHa (deslorelin or histrelin, sc, daily) and were up to 7 yr posttreatment, including 21 postmenarcheal girls who collected weekly overnight urine… CONTINUE READING
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