Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index.

@article{Borman2000OvotoxicityIF,
  title={Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index.},
  author={Sherri M. Borman and Patricia J. Christian and I. Glenn Sipes and Patricia B. Hoyer},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={167 3},
  pages={
          191-8
        }
}
Extensive destruction of primordial follicles by exposure to ovarian toxicants can cause early menopause in women. Primordial follicle destruction is known to result from dosing of mice and rats with three polycyclic aromatic hydrocarbons (PAHs), contaminants commonly found in cigarette smoke. Therefore, the purpose of this study was to compare relative ovotoxicity in mice and rats using the PAHs, 9, 10-dimethylbenzanthracene (DMBA), 3-methylcholanthrene (3-MC), and benzo[a]pyrene (BaP). Female… CONTINUE READING
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