Ovine diseases. Orf.

  title={Ovine diseases. Orf.},
  author={David M. Haig and Andrew Mercer},
  journal={Veterinary research},
  volume={29 3-4},
Orf virus is an epitheliotropic DNA parapoxvirus with a worldwide distribution that induces acute pustular lesions in the skin of sheep, goats and man. Genetic mapping and sequencing of the orf virus genome have revealed that orf virus has a typical poxvirus distribution of genes, with those essential for viral DNA synthesis, replication and packaging located in the central region, and those involved in virulence concentrated in the terminal regions. The immune and inflammatory response to orf… CONTINUE READING