Oviduct: roles in fertilization and early embryo development.

  title={Oviduct: roles in fertilization and early embryo development.},
  author={Shuai Li and Wipawee Winuthayanon},
  journal={The Journal of endocrinology},
  volume={232 1},
Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This review highlights the physiological conditions within the oviduct during fertilization, environmental… 

Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions

The origin and molecular components of the oviductal fluid in mammals, including the embryo itself, as well as ovulation, insemination, endogenous and exogenous hormones, and metabolic and heat stress, are reviewed.

The role of the oviduct and extracellular vesicles during early embryo development in bovine

This review will present the ability of the oviducts based on its dynamic and systemic changes during reproductive events, as well as the contribution of EVs in this process.

Sex Steroid-Mediated Control of Oviductal Function in Cattle

Elevated periovulatory concentrations of estradiol (E2) and progesterone (P4) influence gene expression and morphological changes that have been associated positively to fertility in beef cattle, and prepare the oviductal lumen for interactions with gametes and embryos.

Mechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct

In addition to widely established genetic determinants of Müllerian duct development, the search has identified surprising associations between loss-of-function of several genes and high-penetrance abnormalities in the Müllersian duct and/or oviducts.

Bioengineered microenvironment to culture early embryos

The main strategies which enable researchers to grow embryos outside of the body while overcoming the implantation barrier are summarized, the roles of engineered microenvironments in regulating early embryonic development are highlighted, and the future challenges and new insights of early embryo culture are discussed.

The genes regulating maintenance of cellular protein location are differentially expressed in porcine epithelial oviductal cells during longterm in vitro cultivation

Since the biochemistry and morphology of epithelial cells may change during long term cultivation, the results are a reflection of these changes and help to shed a light on porcine OECs properties in in vitro environment.

Staging mouse preimplantation development in vivo using optical coherence microscopy

An in vivo optical imaging approach is reported enabling high‐resolution visualizations of developing embryos in the mouse oviduct by combining optical coherence microscopy (OCM) and a dorsal imaging window, allowing for the staging of development of preimplantation embryos in vivo.

Metabolomic Analysis Reveals Changes in Preimplantation Embryos Following Fresh or Vitrified Transfer

Target metabolomics findings revealed a significant reduction in some metabolites involved in metabolic pathways, such as the Krebs cycle, amino acids, unsaturated fatty acids, and arachidonic acid metabolisms, which highlight a synergistic effect between the embryo transfer and vitrification procedures in preimplantation embryos.

Extracellular Vesicles Mediated Early Embryo–Maternal Interactions

The role of extracellular vesicles modulating embryo–maternal interactions during early pregnancy is demonstrated and it is shown that embryo-derived EVs might modulate oviductal and uterine function.



Mouse oviduct development.

The process of oviduct development is poorly understood and can be utilized to further knowledge of epithelial-mesenchymal interactions, regulation of coiling, characteristics of pseudostratified epithelia, and smooth muscle differentiation.

In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans

The objective of this review is to update the impact of the various conditions inherent in the use of IVF on the epigenetic profile and outcomes of mammalian embryos, including superovulation, IVF technique, embryo culture and manipulation and absence of embryo-maternal signaling.

Preimplantation embryo metabolism and culture systems: experience from domestic animals and clinical implications

This review emphasizes stage specific shifts in embryo metabolism and requirements and research to optimize in vitro embryo culture conditions and supplementation, with a view to optimizing embryo culture in general, and culture of single embryos in particular.

Improved development of human embryos in vitro by a human oviductal cell co-culture system.

It was concluded that co-culture of human embryos with oviductal cells could improve the development of the embryos in vitro.

Oviductal estrogen receptor α signaling prevents protease-mediated embryo death

Development of uterine endometrial receptivity for implantation is orchestrated by cyclic steroid hormone-mediated signals. It is unknown if these signals are necessary for oviduct function in

Embryo-initiated oviductal transport in mares.

The hypothesis that equine embryos initiate oviductal transport in mares was tested by placing day 6 uterine embryos in the oviducts of day 2 (n = 10) or day 5 (n = 10) recipient mares and attempting

Metabolism of the preimplantation embryo: 40 years on.

This review considers how understanding of preimplantation embryo metabolism has progressed since the pioneering work on this topic in the late 1960s and early 1970s and updates the state of knowledge, listing some future research questions, and some unifying ideas.

Physiology of gamete and embryo transport through the fallopian tube.

Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors.

  • B. PariaS. Dey
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1990
Clear evidence is presented that specific growth factors of embryonic and/or reproductive tract origin participate in preimplantation embryo development and blastocyst functions in an autocrine/paracrine manner.