Overweight and obesity affect treatment response in major depression.

  title={Overweight and obesity affect treatment response in major depression.},
  author={Stefan Kloiber and Marcus Ising and Simone Reppermund and Sonja Horstmann and Tatjana Dose and Matthias Majer and Josef Zihl and Hildegard Pfister and P. G. Unschuld and Florian Holsboer and Susanne Lucae},
  journal={Biological psychiatry},
  volume={62 4},
BACKGROUND Epidemiologic and clinical studies suggest comorbidity between major depressive disorder (MDD) and obesity. To elucidate the impact of weight on the course of depression beyond comorbidity, we investigated psychopathology, attention, neuroendocrinology, weight change, and treatment response in MDD patients, depending on their weight. METHODS Four hundred eight inpatients with MDD participated in the Munich Antidepressant Response Signature Study, designed to discover biomarkers and… CONTINUE READING
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