Overview. Purinergic mechanisms.

  title={Overview. Purinergic mechanisms.},
  author={Geoffrey Burnstock},
  journal={Annals of the New York Academy of Sciences},
  pages={1-17; discussion 18}
An overview of the history of studies of the biological actions of extracellular ATP is presented. The basis of the subdivision of receptors for purines into P1-purinoceptors for adenosine and P2-purinoceptors for ATP and ADP are considered, as well as the recent proposal for subdivision of the ATP receptors into P2X-, P2Y-, P2Z-, and P2T- purinoceptor subtypes. These purinoceptor subtypes are discussed with respect to their transduction mechanisms, their distribution, and their physiological… CONTINUE READING

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