Overview on concepts and applications of Fab antibody fragments.

@article{Rader2009OverviewOC,
  title={Overview on concepts and applications of Fab antibody fragments.},
  author={Christoph Rader},
  journal={Current protocols in protein science},
  year={2009},
  volume={Chapter 6},
  pages={Unit 6.9}
}
In this overview, the Fab molecule is introduced and discussed as the first generated antibody fragment, which still dominates basic research and clinical applications. The unit contains a concepts section and an applications section. In the concepts section, the two principal methods for producing Fab, as well as the generation and directed evolution of Fab by phage display, are described. The applications section discusses Fab in clinical applications, as well as their increasingly important… CONTINUE READING