Overview of tyrosine hydroxylase in Parkinson's disease.

  title={Overview of tyrosine hydroxylase in Parkinson's disease.},
  author={Yanzhen Zhu and Jing Zhang and Yanjun Zeng},
  journal={CNS & neurological disorders drug targets},
  volume={11 4},
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in brain catecholamine biosynthesis, and tetrahydrobiopterin is its cofactor. Research has focused on identifying mechanisms of TH activity regulation. TH activity is modulated by the cofactor itself, and is enhanced by several kinases phosphorylating key serines in the TH regulatory domain. Aside from these, the mechanisms that control TH gene transcription and TH mRNA translation are also related with the regulation of TH activity… CONTINUE READING
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