Overview of total intravenous anesthesia in children

@article{Mani2010OverviewOT,
  title={Overview of total intravenous anesthesia in children},
  author={Vaithianadan Mani and Neil S Morton},
  journal={Pediatric Anesthesia},
  year={2010},
  volume={20}
}
Total intravenous anesthesia (TIVA) can be defined as a technique, in which general anesthesia is induced and maintained using purely i.v. agents. TIVA has become more popular and possible in recent times because of the pharmacokinetic (PK) and pharmacodynamic properties of propofol and the availability of short‐acting synthetic opioids. Also, new concepts in PK modeling and advances in computer technology have allowed the development of sophisticated delivery systems, which make control of… 
View on Wiley
xa.yimg.com
77 Citations
Highly Influential Citations
2
Background Citations
17
Methods Citations
2

77 Citations

Citation Type

Citation Type

Clinical Modifications Induced by Drugs during the Perioperative Period
TLDR
TIVA has become more popular in recent times because of the pharmacokinetic and pharmacodynamic properties of propofol, the availability of short acting synthetic opioids, and the development of delivery systems.
Total Intravenous Anesthesia (TIVA) and Target Controlled Infusions (TCI) in Children
  • N. Morton
  • Medicine
    Current Anesthesiology Reports
  • 2012
TLDR
In the future, more precise dosing and titration will be aided by near-real-time propofol analysis in blood or exhaled gases and further refinement of depth of anesthesia monitoring in children.
Total Intravenous Anesthesia and Target-Controlled Infusion
Total intravenous anesthesia (TIVA) in pediatric cardiac anesthesia
TLDR
Some of the TIVA techniques used in pediatric cardiac anesthesia are reviewed and new concepts in pharmacokinetic modeling and computer technology are introduced.
Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children.
TLDR
The use of processed electroencephalographic monitoring is helpful in pediatric total intravenous anesthesia and target-controlled infusion anesthesia, particularly in the presence of neuromuscular blockade.
Target controlled infusion anaesthesia in children
TLDR
TIVA has grown rapidly in popularity over the last two decades in both adult and paediatric anaesthesia, due to the widespread availability of drugs with favourable pharmacological properties and the development of new concepts in pharmacokinetic modelling.
Inhalation Anesthesia vs. Total Intravenous Anesthesia for Ambulatory Dental Surgery in Children
TLDR
This study evaluated the incidence of PONV and the duration of PACU length of stay in pediatric patients undergoing ambulatory dental surgery as it relates to the quality of recovery including postoperative pain, Post Operative Nausea and Vomiting (PONV), and Post Anesthesia Care Unit (PACU) Length of Stay (LOS) in Pediatrics.
Comparison of target‐controlled infusion and manual infusion for propofol anaesthesia in children†
Anesthesia using target-controlled infusion of propofol during elective pediatric surgery: Kataria versus Paedfusor pharmacokinetic model
TLDR
Kataria and Paedfusor PK models were comparably effective for induction of anesthesia and recovery of pediatric patients, however, Cp at recovery was lower in Kataria than Paed fusor, and there was no significant difference in time of recovery.
Propofol based total intravenous anesthesia versus sevoflurane based inhalation anesthesia: The postoperative characteristics in oral and maxillofacial surgery.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Inhalational anesthesia vs total intravenous anesthesia (TIVA) for pediatric anesthesia
TLDR
An objectively examine the arguments for and against inhalation and TIVA and look at where both techniques could be better adapted in the pediatric population.
Update on TIVA
  • R. Eyres
  • Medicine
    Paediatric anaesthesia
  • 2004
TLDR
It is difficult from the literature alone to assess the frequency of use of total intravenous anesthesia (TIVA) in pediatric anesthetic practice, but as a pure technique, it does not appear to be mainstream.
Pharmacokinetic model driven infusion of propofol in children.
TLDR
A computer controlled infusion device for propofol was used to induce and maintain general anaesthesia in 20 children undergoing minor surgical procedures and it was found that the values obtained were systematically overpredicted by the delivery system algorithm.
Dosing Ketamine for Pediatric Procedural Sedation in the Emergency Department
TLDR
Dosing increases with decreasing age, and a large single dose is associated with deep sedation, possible adverse effects, and delayed recovery, and dose should be tailored to clinical monitoring and requirement.
Effects of Combining Propofol and Alfentanil on Ventilation, Analgesia, Sedation, and Emesis in Human Volunteers
TLDR
The combination of propofol and alfentanil produced greater sedation and analgesia than that with either drug alone, with specific regard to effects on ventilation, analgesia, sedation, and nausea.
Pharmacokinetic and pharmacodynamic interactions between opioids and propofol.
  • J. Vuyk
  • Biology, Medicine
    Journal of clinical anesthesia
  • 1997
The use of propofol infusions in paediatric anaesthesia: a practical guide
TLDR
Children require higher infusion rates than adults to maintain steady state concentrations of 3 μg·ml−1 and have longer context sensitive half‐times than adults and these differences can be attributed to altered pharmacokinetics in this age group.
The Pharmacokinetics of Propofol in Children Using Three Different Data Analysis Approaches
TLDR
The pharmacokinetics of propofol in children are well described by a standard three-compartment pharmacokinetic model and weight was a significant covariate, and the weight-proportional model was supported by all three regression approaches.
Accuracy of the 'Paedfusor' in children undergoing cardiac surgery or catheterization.
TLDR
The Paedfusor performance was found to be within the accepted limits for use as a TCI system and much better than those found with the adult 'Diprifusor' system.
Target controlled infusion of propofol for induction and maintenance of anaesthesia using the paedfusor: an open pilot study
Summary Background: The aim of this study was to evaluate the ease of use and efficacy of the Paedfusor, a computer controlled propofol infusion device with software appropriate for children down to…
...
1
2
3
4
...